PETRA project proposes the development of novel personalized therapies based on modular robotic systems driven by artificial intelligence techniques. PETRA will go beyond the current state of the art: 1) developing modular rehabilitation robotic devices; 2) researching on novel multimodal stimulation system to maximize patient’s motivation and engagement; 3) developing robot-assisted therapies adapted to the patient’s needs and state; 4) investigating on auditory stimulation during sleep to improve the motor learning process; 5) researching on the integration of intention detection components based on various multimodal signals including cortical signals and muscular electrical activity as well as gaze estimation, with shared control systems merging residual natural control by the user and robotic assistance, which ensures that patients perform exercises as actively as possible; 6) developing a Decision Support System for tailoring medical rehabilitation treatment to the individual characteristics of each patient, setting parameters of rehabilitation robotic therapies and classifying individuals into groups that differ in their response to a specific robot assisted rehabilitation treatment; 7) researching on bilateral control strategies for telerehabilitation robotics therapies; and 8) developing a robot-assisted therapy gaming network with cooperative and competitive serious games.